The Emerald of Sicily

Every year at the end of September, in the streets and pizzas of centro storico of Bronte, the Fair of the Pistachio is celebrated.  Bronte is one of the 3 towns on the western slope of Mount Etna in Sicily where the finest pistachios in the world are grown.

The pistachio of Bronte DOP (Europe’s Protected Designation of Origin) has been famous throughout the world since antiquity for its sweet and delicate flavor, its aromatic scent, and its intense green color.  Bronte and its two neighboring towns (Atrano and Biancavilla) produce only about 1% of the world’s pistachios, which has led to illegal selling of pistachios from other countries as originally coming from Bronte.  While 80% of Sicily’s production is exported, the rest is used in many Italian products, ranging from sausage to pasta, from cakes to nougats, from cheeses to biscuits.  The Brontese pistachio gelato is one of the most appreciated in the world.

The story of the harvest is very much tied to the culture and traditions of the area, which have been handed down father to son, mother to daughter, for centuries.  And it is also the story of the land that both survives the volcano and takes advantage of its fertility, and of the ever-unpredictable climate.

The harvest occurs every two years to preserve the quality of the fruit and to avoid excessive exploitation of the plants that are already under stress from, among other things, the frequent periods of drought in the Sicilian summers.  In the alternate years, the trees are pruned cutting “the eyes,” that is, the buds from the branches that grow the shoots.  This guarantees a consistent quality production the following year.

Before machines everything was done by hand, and even now, there are few machines used in the harvest.  The trees grow close to each other clinging to the igneous rock on land that machinery can barely penetrate.  Scissors and hatchets are used to remove the dry branches that no longer produce fruit; the branches must then be burned immediately to avoid being attacked by a parasite that can threaten the entire cultivation.  To facilitate the harvest and to minimize the loss of fruit, black tarps are spread out under the trees.  Workers wear gloves to protect themselves from the stain of the resin.  For the fruit clusters that grow high in the trees, they use a so-called ferra, a stick that is made from a wild fennel plant.  Being soft, it is the only instrument that can be used to strike the branches without ruining them, and at the same time, make the mature pistachios fall to the ground.

After the daily harvest, the nuts are loaded in sacks destined for the smallatura, a simple machine that every Brontese family has for removing the husk that covers the shell.  Then the nuts must be immediately exposed to the sun to promote drying.  Every country house in Bronte is equipped in front with a terrace—not for the people to lounge on, but, in fact to dry the pistachios.

Every Brontese family also knows that the danger to their crops comes from the sky.  In the past, before weather instruments and when roles were gender-based, the grandmothers stayed home to manage the daily operations (including the collection and drying of the nuts on the terrace).  They learned to “read” the sky and the clouds.  As soon as they saw bad weather approaching from the west, they called together the women of the family to collect all the pistachios on the terrace before the rains drenched them.

The harvest is a perpetual struggle—against drought, rains, and parasites—but what’s at stake is the income of many families who base their lives on this fruit.  Two years ago, Bronte produced an exceptional crop, but this year hail came in the middle of May, at the worst possible time when the fruit was small and needed to mature.   There is another tradition rooted in the Brontese culture that even today is passed down from parents to children.  It is the ancient popular belief according to which eating too many pistachios brings on the fever.  Even today, the older folks tell this to the children to dissuade them from eating too many during the harvest and therefore to preserve as much of their precious crop as possible.

 

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Gli sviluppi nella ricerca dell’Alzheimer

Da decenni i ricercatori lavorano per sconfiggere la brutta malattia che fa dimenticare.  Di recente c’è stata una svolta.  Un’équipe di ricercatori del Dipartimento di Fisica dell’Università di Bari, insieme all’Istituto Nazionale di Fisica Nucleare, ha messo a punto un algoritmo che può identificare 10 anni prima le persone che potrebbero sviluppare l’Alzheimer.  A guidare la ricerca in diagnosi precoce è un 29enne, Marianna La Rocca, laureata in fisica e dottoranda all’Università di Bari.

“Intercettare i primi sintomi di Alzheimer e, in particolare, quel declino cognitivo caratterizzato soprattutto dalla perdita di memoria, è importante per due motivi,” secondo la giovane ricercatrice.  “Il primo è che queste persone possono seguire quegli stili di vita che aiutano a prevenire la malattia.  Il secondo è che si possono individuare persone da reclutare negli studi clinici per sperimentare nuove cure in grado di rallentare la malattia.”

Non esiste ancora una cura per l’Alzheimer.  Da più di vent’anni si sperimentano farmaci per frenare la malattia, ma finora invano, salvo pochi che al massimo alleviano qualche sintomo.  Perché?  Tutte le terapie sono iniziate troppo tardi.  Quando compare la demenza la malattia è ormai in stadio avanzata e molti neuroni sono già danneggiati irreparabilmente, perché si è scoperto che le placche di amiloide e gli altri fenomeni degenerativi del cervello sono iniziati 15-20 anni prima.  Aspettare i sintomi per trattare l’Alzheimer è come aspettare che una persona abbia un infarto prima di curargli l’ipertensione.

La squadra di ricercatori dell’università pugliese che ha messo a punto l’algoritmo, hanno sperimentato sulle risonanze di 38 pazienti malati di Alzheimer e 29 di individui sani.  Successivamente l’esperimento è stato ripetuto su 148 persone, di cui 52 sane, 48 malate di Alzheimer, e 48 di pazienti con minori problemi cognitivi che nel giro di dieci anni hanno poi sviluppato l’Alzheimer.  L’intelligenza artificiale è riuscita a distinguere le risonanze delle persone sane da quelle malate nell’86 per cento dei casi e nell’84 per cento (dato più significativo), ed è riuscita a diagnosticare il futuro sviluppo della malattia in quelli che ancora non ne soffrivano.

La nuova tecnica ha anche il vantaggio di essere più economica e meno invasiva di altre finora utilizzate.  La dottoressa La Rocca, che ha una nonna che soffre di questa patologia, dice anche che mentre il metodo è promettente, va ancora perfezionato.  Sarebbe bello, secondo la ricercatrice, poter raccogliere dati da diversi centri italiani e analizzarli, perché a Bari esiste un Centro di calcolo scientifico fra i più importanti in Italia.

 

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Progress in Alzheimer’s Research

For decades researchers have been working to defeat the devastating disease that robs memories.  Now there is a turning point.  A research team from the Department of Physics at the University of Bari, together with Italy’s Institute for Nuclear Physics, has developed an algorithm that can identify those who will get Alzheimer’s 10 years in advance.  Leading the research in early diagnosis is a 29-year old, Marianna La Rocca, a graduate in physics and a doctoral candidate at the University of Bari.

“To intercept the first symptoms of Alzheimer’s and, in particular the cognitive decline characterized especially by the loss of memory, is important for two reasons,” according to the young researcher.  The first is that these people can follow a lifestyle that helps to prevent the disease.  The second is that we can identify people to recruit for clinical studies to test new cures capable of slowing the disease.”

A cure does not yet exist for Alzheimer’s.  For more than 20 years drugs have been tried to slow the disease, but in vain so far, except for a few that at most alleviate some symptoms.  Why?  Any therapy has been initiated too late.  When dementia appears, the disease by then is advanced and many neurons are already damaged irreparably, because the amyloid plaques and other degenerative phenomenon of the brain began 15-20 years earlier.  To wait for the symptoms to appear in order to treat Alzheimer’s is like waiting for a person who has an infarct before curing hypertension.

The research team at the Pugliese university that developed the algorithm, had experimented with resonance imaging of 38 patients with Alzheimer’s and 29 healthy individuals.  Subsequently, the experiment was repeated on 148 people of which 52 were healthy, 48 had the disease, and 48 had minor cognitive problems that in the course of 10 years became Alzheimer’s.  The artificial intelligence managed to distinguish the resonance imaging of the healthy from the ill in 86% and 84% of the cases, and managed to diagnose the future development of the disease in those who were not yet suffering from it.

The new technique also has the advantage of being more economical and less invasive than other techniques used up until now.  La Rocca, who has a grandmother suffering from Alzheimer’s, says that while their method is promising, it still needs improvement.  It would be great, according to the researcher, if they could collect and analyze data from different Italian centers because Bari has a Center for scientific evaluations that is among the most important in the country.

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